Demographic-Adjusted Maximal Wall Thickness (MWT) Reference for Hypertrophic Cardiomyopathy (HCM)

A research-based tool for estimating normal left ventricular wall thickness based on age, sex, and body size.

Developed by Dr. Hunain Shiwani at UCL and Barts Heart Centre

Based on: Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis

Last Update: 12th February 2025

⚠️ NOT FOR CLINICAL USE - This is a research and educational tool only. Results should not be used for clinical decision-making. All calculations are performed locally in your browser and no information is stored or transmitted.

Demographics

⚠️ Research Use Only - By using this tool, you agree that you are entering simulated or anonymized data for educational purposes only. No information is stored or transmitted. Rate limiting is in place to prevent bulk usage.

Click the button above to proceed to the calculator

Results

Predicted LVH Threshold (Upper Limit of Normal)
- (-.- mm)
Predicted MWT
- (-.- mm)
Z-Score
-

When to Use

This tool provides demographic-adjusted reference values for Maximal Wall Thickness (MWT) based on age, sex, and body size (BSA) for Hypertrophic Cardiomyopathy (HCM). It generates an LVH threshold and z-score to help contextualize MWT values in relation to established reference data.

🛑 This tool is for informational and research purposes only. It is not a diagnostic device and should not be used to make clinical decisions without expert evaluation.

Important points

  • Not a diagnostic tool → Provides reference values, not a clinical diagnosis. Results should be interpreted in the context of full clinical evaluation.
  • Validated with Cardiac MRI data → This tool was developed using CMR measurements, which may differ from echocardiographic findings.
  • Optimized for ages 20-80 years → Accuracy may be limited outside this range or in extreme BSA values.
  • For clinicians and researchers → This tool is intended to support research and clinical discussions rather than serve as a standalone decision-making tool.

Results

Predicted Upper Limit of Normal
- (-.- mm)
Predicted MWT
- (-.- mm)
Z-Score
-

Clinical Considerations

LVH Threshold: The upper reference range (95% prediction interval) for maximal wall thickness based on population data.

Predicted MWT: The modeled "expected" wall thickness in healthy patients with similar demographics.

Z-Score: The number of standard deviations the patient's observed MWT deviates from the predicted mean. A measure of how the observed MWT compares to population norms. A higher z-score does not confirm disease but may indicate further evaluation is warranted.

References