Demographic-Adjusted Maximal Wall Thickness (MWT) Reference for Hypertrophic Cardiomyopathy (HCM)

A research-based tool for estimating normal left ventricular wall thickness based on age, sex, and body size.

Developed by Dr. Hunain Shiwani at UCL and Barts Heart Centre

Based on: Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis

Last Update: 12th February 2025

Demographics

Valid range: 20-80 years

Height & Weight
BSA

Normal range: 1.2-2.5 m²

Valid range: 6-40 mm

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Results

LVH Threshold (Upper Limit of Normal)
- (-.- mm)
Predicted MWT
- (-.- mm)
Z-Score
-

When to Use

This tool provides demographic-adjusted reference values for Maximal Wall Thickness (MWT) based on age, sex, and body size (BSA) for Hypertrophic Cardiomyopathy (HCM). It generates an LVH threshold and z-score to help contextualize MWT values in relation to established reference data.

🛑 This tool is for informational and research purposes only. It is not a diagnostic device and should not be used to make clinical decisions without expert evaluation.

Important points

  • Not a diagnostic tool → Provides reference values, not a clinical diagnosis. Results should be interpreted in the context of full clinical evaluation.
  • Validated with Cardiac MRI data → This tool was developed using CMR measurements, which may differ from echocardiographic findings.
  • Optimized for ages 20-80 years → Accuracy may be limited outside this range or in extreme BSA values.
  • For clinicians and researchers → This tool is intended to support research and clinical discussions rather than serve as a standalone decision-making tool.

Results

LVH Threshold (Upper Limit of Normal)
- (-.- mm)
Predicted MWT
- (-.- mm)
Z-Score
-

Clinical Considerations

LVH Threshold: The upper reference range (95% prediction interval) for maximal wall thickness based on population data.

Predicted MWT: The modeled "expected" wall thickness in healthy patients with similar demographics.

Z-Score: The number of standard deviations the patient's observed MWT deviates from the predicted mean. A measure of how the observed MWT compares to population norms. A higher z-score does not confirm disease but may indicate further evaluation is warranted.

References